apalutamide will lower the level or impact of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with prescription drugs which can be CYP3A4 substrates can result in lower exposure to those drugs.WEBWYMZYA Fe can be initiated no pr